URL call was terminated because the corresponding service is not available

Hi Experts,

Post Ehp7 Upgrade we are facing an issue where we are trying to hit a URL it is not working and shows the attached error.

But, when we try to test the same service in SICF it is working fine with all the instance (we have 4 instance for this system).

Maintained all the instances FQDN in the profile parameter, maintained the setting change in SE80.

Please do suggest any solution for this ASAP.

Thanks,

Preetha Balan